2021.12.08 08:53 SHIT-CHRIS Gremlins, an absolute classic - Day 8 of my 25 day Christmas horror film showcase!
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2021.12.08 08:53 Gloomy-Bother6498 Please ignore the tick marks and ans Bata do
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2021.12.08 08:53 ArvengusYT Top 10 anime betrayals
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2021.12.08 08:53 Acissye I rly dont know what i was thinking doing this photoshoot with my OC Keloma (Info in comments)
2021.12.08 08:53 EugeneOlivier71717 What is the most hypocritical thing you have ever witnessed?
2021.12.08 08:53 braisingsteak Formatting Dates in 4 Different Datasets
First post on here so please bare with me I apologise in advance for any errors but would really appreciate some help.
I have 4 different Datasets I am trying to plot on to 2 double axis line charts, for this to happen the dates need to be in the same format (see attached images of data sets: Dataset 1, Dataset 2, Dataset 3, Dataset 4)
I would like the universal format to be "31-01-2020".
For Dataset 1 2020 Jan = 31-01-2020, For Dataset 2 this seems pretty simple they just need reversing in order so 2020-01-31 = 31-01-2020, For Dataset 3 Q1 2019 = 31-03-2019 & Q2 2019 = 31-06-2019 etc., For Dataset 4 2020 JAN = 31-01-2020 & 2020 FEB = 31-02-2020 etc.
Is there anyway I can apply the format across all the data sets? Any help would be much appreciate I haven't supplied any code as I don't know where to start with this problem. I have the lubridate package installed.
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2021.12.08 08:52 procryptoclass CAKEnergy.finance – Play and earn on Binance Smart Chain
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2021.12.08 08:52 pcyw01throw Will taking something like st john’s wort (hypothetically) during no-pill week reduce efficacy of combined pills?
Will i still be protected from past sex? And what about sex after the break? I know it tends to be youre protected after 7 full days on the pill (for the latter question)
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2021.12.08 08:52 Eazy705 Natural Immunity
From the beginning of the March 2020 lockdowns for the SARS-CoV-2 virus, the subject of natural immunity (also called post-infection immunity) has been neglected. Once the vaccination became widely available, what began with near silence at the beginning turned nearly into a complete blackout of the topic.
[Editorial note: This article has since been upgraded to another piece chronicling 81 studies.]
Even now, there is an absence of open discussion, presumably in the interests of promoting universal vaccination and required documentation of such vaccination as a condition of participating in public life and even the jobs marketplace. Still, the science exists. Many studies exist. Their authors deserve credit, recognition, and to have their voices heard.
These studies demonstrate what was and is already known: natural immunity for a SARS-type virus is robust, long-lasting, and broadly effective even in the case of mutations, generally more so than vaccines. In fact, a major contribution of 20th-century science has been to expand upon and further elucidate this principle that has been known since the ancient world. Every expert presumably knew this long before the current debates. The effort to pretend otherwise is a scientific scandal of the highest order, especially because the continued neglect of the topic is affecting the rights and freedoms of billions of people.
People who have contracted the virus and recovered deserve recognition. The realization that natural immunity – which pertains now to perhaps half of the US population and billions around the world – is effective in providing protection should have a dramatic effect on vaccine mandates.
Individuals whose livelihoods and liberties are being deprecated and deleted need access to the scientific literature as it pertains to this virus. They should send a link to this page far and wide. The scientists have not been silent; they just haven’t received the public attention they deserve. The preparation of this list was assisted by links provided by Paul Elias Alexander and Rational Ground’s own cheat sheet on natural immunity, which also includes links to popular articles on the topic.
One-year sustained cellular and humoral immunities of COVID-19 convalescents, by Jie Zhang, Hao Lin, Beiwei Ye, Min Zhao, Jianbo Zhan, et al. Clinical Infectious Diseases, October 5, 2021. “SARS-CoV-2-specific IgG antibodies, and also NAb can persist among over 95% COVID-19 convalescents from 6 months to 12 months after disease onset. At least 19/71 (26%) of COVID-19 convalescents (double positive in ELISA and MCLIA) had detectable circulating IgM antibody against SARS-CoV-2 at 12m post-disease onset. Notably, the percentages of convalescents with positive SARS-CoV-2-specific T-cell responses (at least one of the SARS-CoV-2 antigen S1, S2, M and N protein) were 71/76 (93%) and 67/73 (92%) at 6m and 12m, respectively. Furthermore, both antibody and T-cell memory levels of the convalescents were positively associated with their disease severity.”
Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections, by Sivan Gazit, Roei Shlezinger, Galit Perez, Roni Lotan, Asaf Peretz, Amir Ben-Tov, Dani Cohen, Khitam Muhsen, Gabriel Chodick, Tal Patalon. MedRxiv, August 25, 2021. “Our analysis demonstrates that SARS-CoV-2-naïve vaccinees had a 13.06-fold increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant for a symptomatic disease as well…. This analysis demonstrated that natural immunity affords longer lasting and stronger protection against infection, symptomatic disease and hospitalization due to the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity.”
Shedding of Infectious SARS-CoV-2 Despite Vaccination, by Kasen K. Riemersma, Brittany E. Grogan, Amanda Kita-Yarbro, Gunnar E. Jeppson, David H. O’Connor, Thomas C. Friedrich, Katarina M. Grande, MedRxiv, August 24, 2021. “The SARS-CoV-2 Delta variant might cause high viral loads, is highly transmissible, and contains mutations that confer partial immune escape. Outbreak investigations suggest that vaccinated persons can spread Delta. We compared RT-PCR cycle threshold (Ct) data from 699 swab specimens collected in Wisconsin 29 June through 31 July 2021 and tested with a qualitative assay by a single contract laboratory. Specimens came from residents of 36 counties, most in southern and southeastern Wisconsin, and 81% of cases were not associated with an outbreak. During this time, estimated prevalence of Delta variants in Wisconsin increased from 69% to over 95%. Vaccination status was determined via self-reporting and state immunization records.”
Necessity of COVID-19 vaccination in previously infected individuals, by Nabin K. Shrestha, Patrick C. Burke, Amy S. Nowacki, Paul Terpeluk, Steven M. Gordon, MedRxiv, June 5, 2021. “Individuals who have had SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination, and vaccines can be safely prioritized to those who have not been infected before.”
Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection, by Ariel Israel, Yotam Shenhar, Ilan Green, Eugene Merzon, Avivit Golan-Cohen, Alejandro A Schäffer, Eytan Ruppin, Shlomo Vinker, Eli Magen. MedRxiv, August 22, 2021. “This study demonstrates individuals who received the Pfizer-BioNTech mRNA vaccine have different kinetics of antibody levels compared to patients who had been infected with the SARS-CoV-2 virus, with higher initial levels but a much faster exponential decrease in the first group.”
Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus Infection, by Ellie Ivanova, Joseph Devlin, et al. Cell, May 2021. “While both infection and vaccination induced robust innate and adaptive immune responses, our analysis revealed significant qualitative differences between the two types of immune challenges. In COVID-19 patients, immune responses were characterized by a highly augmented interferon response which was largely absent in vaccine recipients.”
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans, by Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Charles W. Goss, Adriana M. Rauseo, Aaron J. Schmitz, Lena Hansen, Alem Haile, Michael K. Klebert, Iskra Pusic, Jane A. O’Halloran, Rachel M. Presti, Ali H. Ellebedy. Nature, May 24, 2021. “This study sought to determine whether infection with SARS-CoV-2 induces antigen-specific long-lived BMPCs in humans. We detected SARS-CoV-2 S-specific BMPCs in bone marrow aspirates from 15 out of 19 convalescent individuals, and in none from the 11 control participants…. Overall, our results are consistent with SARS-CoV-2 infection eliciting a canonical T-cell-dependent B cell response, in which an early transient burst of extrafollicular plasmablasts generates a wave of serum antibodies that decline relatively quickly. This is followed by more stably maintained levels of serum antibodies that are supported by long-lived BMPCs.”
Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells, by Kristen W. Cohen, Susanne L. Linderman, Zoe Moodie, Julie Czartoski, Lilin Lai, Grace Mantus, Carson Norwood, Lindsay E. Nyhoff, Venkata Viswanadh Edara, et al. MedRxiv, April 27, 2021. “Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. We evaluated 254 COVID-19 patients longitudinally from early infection and for eight months thereafter and found a predominant broad-based immune memory response. SARS-CoV-2 spike binding and neutralizing antibodies exhibited a bi-phasic decay with an extended half-life of >200 days suggesting the generation of longer-lived plasma cells. In addition, there was a sustained IgG+ memory B cell response, which bodes well for a rapid antibody response upon virus re-exposure.”
Incidence of Severe Acute Respiratory Syndrome Coronavirus-2 infection among previously infected or vaccinated employees, by N Kojima, A Roshani, M Brobeck, A Baca, JD Klausner. MedRxiv, July 8, 2021. “Previous SARS-CoV-2 infection and vaccination for SARS-CoV-2 were associated with decreased risk for infection or re-infection with SARS-CoV-2 in a routinely screened workforce. The was no difference in the infection incidence between vaccinated individuals and individuals with previous infection. Further research is needed to determine whether our results are consistent with the emergence of new SARS-CoV-2 variants.”
Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccine, by Suhas Sureshchandra, Sloan A. Lewis, Brianna Doratt, Allen Jankeel, Izabela Ibraim, Ilhem Messaoudi. BioRxiv, July 15, 2021. “Interestingly, clonally expanded CD8 T cells were observed in every vaccinee, as observed following natural infection. TCR gene usage, however, was variable, reflecting the diversity of repertoires and MHC polymorphism in the human population. Natural infection induced expansion of larger CD8 T cell clones occupied distinct clusters, likely due to the recognition of a broader set of viral epitopes presented by the virus not seen in the mRNA vaccine. Our study highlights a coordinated adaptive immune response where early CD4 T cell responses facilitate the development of the B cell response and substantial expansion of effector CD8 T cells, together capable of contributing to future recall responses.”
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status, Jason Neidleman, Xiaoyu Luo, Matthew McGregor, Guorui Xie, Victoria Murray, Warner C. Greene, Sulggi A. Lee, Nadia R. Roan. BioRxiv, July 29, 2021. “In infection-naïve individuals, the second dose boosted the quantity and altered the phenotypic properties of SARS-CoV-2-specific T cells, while in convalescents the second dose changed neither. Spike-specific T cells from convalescent vaccinees differed strikingly from those of infection-naïve vaccinees, with phenotypic features suggesting superior long-term persistence and ability to home to the respiratory tract including the nasopharynx. These results provide reassurance that vaccine-elicited T cells respond robustly to emerging viral variants, confirm that convalescents may not need a second vaccine dose, and suggest that vaccinated convalescents may have more persistent nasopharynx-homing SARS-CoV-2-specific T cells compared to their infection-naïve counterparts.”
2021.12.08 08:52 TheChamberPlaylist Kanye West Explains His Songwriting Secrets
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2021.12.08 08:52 bear_blu [OC] The World's Highest Paid Athletes - 1990/2021
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2021.12.08 08:52 Ok_Excitement7576 21 [F4M] jingle bells "meta"
all house I heard christmas songs.. who wants to invite me im gonna sing using your long microphone 😋😋 you know what I mean haha, the whole day and night loool. sn4p me on a_rain3809
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2021.12.08 08:52 mrmadara Send answer please thanks
2021.12.08 08:52 Destruction0 Serenity Peak
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2021.12.08 08:52 INOICAN Sign from the universe that I need to buy more CRO.. v2?🤔
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2021.12.08 08:52 Akardyagain Spread on miniguns has been reduced.
Didn't notice any update this morning and not sure if anything else has been changed but 100% certain spread on heli mini guns has gone way down. I actually killed someone by aiming at them from 100m away this morning.
Not sure how I feel about it. On the hand the spread was ridiculous and using those mini guns was basically useless. But on the other hand I'm not sure more of infantry getting mowed down by heli's is what the game needed.
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2021.12.08 08:52 SHIT-CHRIS Gremlins, an absolute classic - Day 8 of my 25 day Christmas horror film showcase!
2021.12.08 08:52 Sketzu 🦅 Military.Finance🦅 Crytpo for veterans!! 🔥The Great Demonstration🔥
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We’ve built an entire $MIL ecosystem around our BSC MIL and will be launching a new governance token on the ETH network around end of year!
🔸BSC: 0xf5015995376a35b10dcbd96ba6b6e9de1c9f87c5 🔸ETH: Launching soon & will burn MIL BSC to never stop growing!!!! The $MIL ecosystem will be an unstoppable force in the crypto world 🦅
🔸 https://t.me/Mil_Finance_NFT 🔸Website : military.finance 🔸 Twitter : https://twitter.com/Mil_Finance?t=qFt0YMEsL_NMfjZ8wNO7PQ&s=09 🔸 Reddit : https://www.reddit.com/Military_Finance?utm_medium=android_app&utm_source=share
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2021.12.08 08:52 alex-VVV Top 15 Most Popular Spotify Artists by Monthly listeners (Sep 2015 - Dec 2021)
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2021.12.08 08:52 robertraur This Friday (12/10) The Manship Presents Harry Potter and The Prisoner of Azkaban Spoof Night at 7:30
Come celebrate the 3rd of 8 Harry Potter movies (but first in hour hearts) this Friday at the Manship with The Family Dinner Improv Troupe.
If you've never been to one of these shows, its similar to Mystery Science Theater 3000 with a live riffing of the movie. There will also be games and prizes for all.
Tickets can be bought at the Manship Website, and check out other Manship events like our improv show on Januay 14th or Twister spoof night on March 4th.
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2021.12.08 08:52 Gowithbest78 Business ideas of Cosmetics
Beauty and beauty products have always found a favorable audience and continue to be popular and sought after products, thus making beauty and cosmetic products a serious business opportunity that is witnessing a steady and consistent growth. This growth and demand for cosmetic products is seen more so now especially in the times of social media platforms, video blogs and Instagram, when every new cosmetic product is tried, tested, promoted and advertised via several influencers and celebrities.
Cosmetics business is evergreen & popular sector that has several new products being introduced routinely and is something that most individuals require routinely.
Cosmetics refers to products and solutions used for skincare, nails, haircare, complexion, which take care of them and help enhance the skin, hair, nails, complexion, thus further resulting in an overall enhancement of one’s appearance.
If you want to get extra details of good Teeth whitening product then drop me a mail at growwithbest78@gmail. com ( remove space in mail)
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2021.12.08 08:52 willdoitomorrow Family still hangs out with family member that touched us
About 2 years ago our extended family started hanging out more often and getting more close after a long time. We would always talk and keep in touch but it was mostly for holidays and that. We now hang out pretty much weekly. But about 7 months ago i was touched inappropriately by one of them. I was 19 than, he was around 75. I never intended to tell anyone untill a thought started creepying in that he may do something similar to my little cousins. I asked them both about it, but never directly. I asked "Did u greet him? How did he greet you? Did he act weird?" ect... It was than that my 12 year old cousin told me that he has touched her too on multiple occasions and would always ask her weird love and sexual questions. My stomach absolutely dropped. I made sure that she was comfortable and we made a deal to tell our parents the same day. I was scared shitless because i expected people to flip out. But instead none of them really seemed to care, especially her mom and dad (my aunt and uncle). In fact, they all made 100 excuses for it while saying "it doesn't excuse it BUT...." My mom even ended up yelling at me because i told her infront of my brother because now she was worried he was gonnna do something to him. I felt so alone after that and never talked to anyone about it again. My aunt called him few days later and confronted him. All she said was that "we're girls and he's not supossed to act like this with us". She told his wife and daughter just so they know too. Since than we pretty much never talked about it again. My side of the family cut ties with him but he still comes around to my aunts and they all hang out with him, acting like nothing ever happened. He has refused to come many time because he's embarrassed about it and knows we don't want him there - that would be great if my aunt wouldn't literally yell at him, telling him he's always welcomed and that we all want him there. I have seen how it has effected my cousin and it breaks my heart. She always hides in her room when they come and refuses to come down. I make sure to always stay with her but like ??Why does she need to hide in her own home?? My family is very opinionated, loud and hotheaded. I have no idea why this was the issues they all decided to stay quiet calm and collected about. I later found out that he has done this to another 14 year old hitchhiker girl he picked up from school. I AM SICK OF PRETENDING THIS IS NORMAL
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2021.12.08 08:52 Psychological-Ad181 Kaos Corpus
We are an anime, gaming loving and chill community.
Looking for people to play instead of playing with randoms?
Feel free to take a look and help us grow together.
PS: yes you can have your own private voice channel for you and your friends
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2021.12.08 08:52 CookieMisha Bug: can't buy any TFT coins ever since they released. Local small currency, therefore no bundles available. :(
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2021.12.08 08:52 dracogoat I literally cannot play the game.
Title. When the game opens, I just get message about the sprites messing everything up. It's been like this since I opened Hearthstone 12 hours ago. Any fixes? Stupid sprites ):-v
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